Perioperative discontinuation of renin–angiotensin system inhibitors in non-cardiac surgery: is it time to change what we tell our patients?

Graphical Abstract How should recommendations regarding perioperative discontinuation vs continuation of renin-angiotensin system inhibitors (RASIs), in patients undergoing non-cardiac surgery, change, consistently with the change in evidence? The 2022 European Society of Cardiology guidelines suggested that withholding RASIs on the day of surgery may be considered to prevent perioperative hypotension, mainly based on observational studies and …