Investigation of the effect of yeast NADH dehydrogenase (NDI1) on the radiation-induced bystander response in HCT116 cells with wild-type p53 function

PURPOSE: Radiation-induced bystander effects describe the biological effects in unirradiated cells induced by signals from nearby radiation-targeted cells. Although the bystander effect has been well demonstrated in cell cultures, the mechanisms underlying how bystander signaling induces mitochondrial dysfunction and metabolic alterations are not fully understood. Of interest to this study is the impairment of mitochondrial Complex I's function …