Figure 2 from The Germline and Somatic Origins of...

Figure 2 from The Germline and Somatic Origins of Prostate Cancer Heterogeneity

Abstract

<p>Somatic driver mutations in localized prostate cancer. Driver mutation discovery in 666 localized prostate tumors. The top barplot shows the distribution of the number of drivers in patients; the covariates on the left show the region type and statistical significance from ActiveDriverWGS and GISTIC. The top heatmap shows drivers found in this study (rows) for each patient (columns). The bottom heatmap shows drivers found in an exome meta-analysis (<a href="#bib14" target="_blank">14</a>). Heatmaps are colored by mutation type. Right barplot shows the number of drivers per patient. Bottom covariate bars show clinical features of patients. Gene labels on the left are for rows identified by tick-marks on the axis. Schematics above each set of legends indicate the panels to which they apply in yellow. For example, the top set of legends apply to the regional covariate heatmaps on the left side of the plot.</p>

Authors

Yamaguchi TN; Houlahan KE; Zhu H; Kurganovs N; Livingstone J; Fox NS; Yuan J; Sietsma Penington J; Jung C-H; Schwarz T

Publication Date

May 2, 2025

DOI

10.1158/2159-8290.28918330

Associated Experts

Katie Houlahan

Assistant Professor, Faculty of Health Sciences

Visit profile

View published work (Non-McMaster Users)

Contact the Experts team

Get technical help

Provide website feedback