Non-Targeted Analysis Workflow of Endocrine-Disrupting Chemicals in Ovarian Follicular Fluid: Identification of Parabens by Diagnostic Fragmentation Evidence and Additional Contaminants via Mass Spectral Library Matching

Ubiquitously distributed in the environment, food supply, and consumer products, endocrine-disrupting chemicals (EDCs) are exogenous substances that disrupt hormonal activities in the endocrine system. Increasing evidence suggests that women with reproductive disorders tend to accumulate higher levels of EDCs, such as phthalates and parabens, in ovarian follicular fluid. However, most existing studies focus on the measurements of a limited …