Journal article
Adherent-invasive Escherichia coli in Crohn’s disease: the 25th anniversary
Abstract
In 1998, Arlette Darfeuille-Michaud, Christel Neut and Jean-Frederic Colombel discovered a novel pathovar of Escherichia coli, adherent and invasive Escherichia coli (AIEC), in the ileum of patients with Crohn's disease (CD), that was genetically distinct from diarrheagenic E. coli, could adhere to and invade intestinal epithelial cells and survive in macrophages. The consistent association between AIEC and CD (approximately 30% across the …
Authors
Barnich N; Arthur JC; Buisson A; Campbell BJ; Carbonnel F; Chassaing B; Coombes BK; Denizot J; Dogan B; Faith J
Journal
Gut, Vol. 75, No. 2, pp. 411–424
Publisher
BMJ
Publication Date
February 1, 2026
DOI
10.1136/gutjnl-2025-335331
ISSN
0017-5749