Journal article
LYSOPHOSPHATIDYLCHOLINE (LPC) AND LYSOPHOSPHATIDIC ACID (LPA) INDUCE NEURONAL ACTIVATION AND HAVE DIFFERENTIAL EFFECTS ON ENTERIC GLIAL CELLS AND SPLENOCYTES
Abstract
Abstract BACKGROUND Chronic abdominal pain is common in patients with chronic gastrointestinal disorders, including Inflammatory Bowel Disease (IBD). Accumulating data suggests that the metabolism of bioactive lipids, such as LPC and LPA, is altered in patients with IBD. We have found that fecal microbiota transplantation from patients with chronic pain and high fecal LPC/LPA levels induces visceral hypersensitivity in the recipient mice. …
Authors
Hall-Bruce M; Pujo J; Lu J; De Palma G; Collins S; Bercik P
Journal
Inflammatory Bowel Diseases, Vol. 31, No. Supplement_1, pp. s54–s54
Publisher
Oxford University Press (OUP)
Publication Date
February 28, 2025
DOI
10.1093/ibd/izae282.129
ISSN
1078-0998