Microglia regulate neuronal activity via structural remodeling of astrocytes

Summary Neuron-glia interactions play a central role in regulating synaptic transmission and neuronal excitability. Structural plasticity of astrocytes is associated with numerous physiological and pathological conditions, however, the mechanism underlying this process remains unknown. To examine the basis for structural astrocyte plasticity, we used the classic example of the loss of astrocytic processes that takes place in the hypothalamic …