Journal article
Contractile abnormalities of mouse muscles expressing hyperkalemic periodic paralysis mutant NaV1.4 channels do not correlate with Na+ influx or channel content
Abstract
Hyperkalemic periodic paralysis (HyperKPP) is characterized by myotonic discharges that occur between episodic attacks of paralysis. Individuals with HyperKPP rarely suffer respiratory distress even though diaphragm muscle expresses the same defective Na(+) channel isoform (NaV1.4) that causes symptoms in limb muscles. We tested the hypothesis that the extent of the HyperKPP phenotype (low force generation and shift toward oxidative type I and …
Authors
Lucas B; Ammar T; Khogali S; DeJong D; Barbalinardo M; Nishi C; Hayward LJ; Renaud J-M
Journal
Physiological Genomics, Vol. 46, No. 11, pp. 385–397
Publisher
American Physiological Society
Publication Date
June 1, 2014
DOI
10.1152/physiolgenomics.00166.2013
ISSN
1094-8341