Journal article
EXTH-24. THERAPEUTIC TARGETING OF MISLOCALIZED NUCLEAR ENVELOPE PROTEINS INMYC-DRIVEN GROUP 3 MEDULLOBLASTOMA
Abstract
Abstract Medulloblastoma (MB) is the most common, malignant pediatric brain tumour comprised of four distinct molecular subgroups (WNT, SHH, Group 3, and Group 4). A subset of Group 3 MB tumors harbors focal amplifications of the MYC oncogene (MYC-G3MB) and are particularly prone to tumour recurrence due to their highly proliferative nature linked to its embryonic stem cell-of-origin and programming. We discovered that LBR, an inner nuclear …
Authors
Suk Y; Ibañez-Vega J; Chaudhry I; Rossotti M; Subapanditha M; Miletic P; Custers S; Escudero L; Delaidelli A; Nakashima T
Journal
Neuro-Oncology, Vol. 26, No. Supplement_8, pp. viii242–viii242
Publisher
Oxford University Press (OUP)
Publication Date
November 11, 2024
DOI
10.1093/neuonc/noae165.0955
ISSN
1522-8517