Hypothalamic Mediation of Growth Hormone and Adrenal Stress Response in the Squirrel Monkey

Hypothalamic lesions were produced in the squirrel monkey in order to identify the neural pathways by which the emotional stimulus of capture and the stress of ether anesthesia bring about growth hormone (GH) hypersecretion. Plasma GH levels were determined by human GH radioimmunoassay. As an index of pituitary-adrenal activation in these animals, plasma corticoids were measured by competitive binding assay. In unlesioned animals capture led to …