A Zwitterionic Anti-Fouling Coating Promotes Electrochemical Biosensing in Complex Media

Biofoulants present in complex media, such as blood, plasma, saliva, etc., can cause an increase in the background of the signal or a reduction in signal-to-noise ratio, due to which most biosensors require a sample processing step. One of the major interactions for biofouling in biosensing platforms is non-specific hydrophobic interactions, which can be prevented using hydrophilic polymeric coatings [1], [2]. However, most hydrophilic polymers …