Journal article
Improved thermal stabilization of VSV-vector with enhanced vacuum drying in pullulan and trehalose-based films
Abstract
One major limitation of effective vaccine delivery is its dependency on a robust cold chain infrastructure. While Vesicular stomatitis virus (VSV) has been demonstrated to be an effective viral vaccine vector for diseases including Ebola, its −70 °C storage requirement is a significant limitation for accessing disadvantaged locations and populations. Previous work has shown thermal stabilization of viral vaccines with a combination of pullulan …
Authors
Iwashkiw JA; Mohamud AO; Kazhdan N; Ameen A; Beecher JE; Filipe CDM; Lichty BD
Journal
Scientific Reports, Vol. 14, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41598-024-69003-4
ISSN
2045-2322