1204 Preventing nausea and vomiting during days 2–7 following high dose cisplatin chemotherapy (HDCP)

The combination of dexamethasone (D) and granisetron (G), a selective 5HT3, receptor antagonist, has greatly reduced the incidence of emesis and nausea in the first 24 hours after HDCP (≥50mg/m2). How best to control emesis after this time remains a key problem in patient management. Our double-blind multicentre trial addressed the issue by detertnining whether the addition of G to D enhanced the efficacy of D alone in controlling emesis beyond …