Preprint
Nephroprotective effects of cilastatin in people at risk of acute kidney injury: A systematic review and meta-analysis
Abstract
ABSTRACT Rationale & Objective Cilastatin is an inhibitor of drug metabolism in the proximal tubule that demonstrates nephroprotective effects in animals. It has been used in humans in combination with the antibiotic imipenem to prevent imipenem’s degradation. This systematic review and meta-analysis evaluated the nephroprotective effects of cilastatin in humans. Study Design Systematic review and meta-analysis of observational (comparative …
Authors
Acharya D; Ghanim F; Harrison TG; Scory TD; Shommu N; Ronksley PE; Elliott MJ; Collister D; Pannu N; James MT
DOI
10.1101/2024.03.06.24303823
Preprint server
medRxiv