Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

ABSTRACT Delay discounting ( DD ), which is the tendency to discount the value of delayed versus current rewards, is elevated in a constellation of diseases and behavioral conditions. We performed a genome-wide association study of DD using 23,127 research participants of European ancestry. The most significantly associated SNP was rs6528024 ( P = 2.40 × 10 −8 ), which is located in an intron of the gene GPM6B . We also showed that 12% of the variance in DD was accounted for by genotype, and that the genetic signature of DD overlapped with attention-deficit/hyperactivity disorder, schizophrenia, major depression, smoking, personality, cognition, and body weight.