Non-inferiority Randomized Controlled Trials

Clinical trialists may explore competing interventionsIntervention, not to demonstrate the superiority of one over the other, but instead to determine if a new therapy that is less burdensome, costly, or with lower risksRisk of harms is not substantially less effective than the existing standard of care. This type of study is called a non-inferiorityNon-inferioritytrialTrial. This chapter describes an approach to assessing the validityValidity …