Chronic Immune Activation and CD4+ T Cell Lymphopenia in Healthy African Individuals: Perspectives for SARS-CoV-2 Vaccine Efficacy

Abstract

Chronic immune activation has been considered as the driving force for CD4⁺ T cell depletion in people infected with HIV-1. Interestingly, the normal immune profile of adult HIV-negative individuals living in Africa also exhibit chronic immune activation, reminiscent of that observed in HIV-1 infected individuals. It is characterized by increased levels of soluble immune activation markers, such as the cytokines interleukin (IL)-4, IL-10, …

Authors

Wolday D; Ndungu FM; Gómez-Pérez GP; de Wit TFR

Journal

Frontiers in Immunology, Vol. 12, ,

Publisher

Frontiers

DOI

10.3389/fimmu.2021.693269

ISSN

1664-3224

Associated Experts

Dawit Wolday

Associate Professor, Faculty of Health Sciences

Visit profile

Labels