Sex-Related Differences in Platelet Aggregation: Influence of the Hematocrit

A number of investigators have recently reported that human female platelets have increased reactivity in vitro compared to platelets from age-matched males. A possible explanation for these observations is that the lower hematocrit in females results in a larger volume of distribution of the anticoagulant, with resultant higher ionized calcium concentrations. To examine this possibility, we performed adenosine diphosphate (ADP) and collagen …