The Quantitation of Platelet-Associated IgG on Cohorts of Platelets Separated From Healthy Individuals by Buoyant Density Centrifugation

Abstract Evidence suggests that as platelets age in the circulation they become progressively smaller and less dense through the loss of protein. The smallest, least dense platelets have a significantly shortened survival, but the mechanism of clearance of these platelets is not known. To evaluate whether the binding of IgG could play a role in the clearance of senescent platelets, we measured platelet size, total protein, and …