Electrochemical Biosensors for Clinical Analysis

In this talk, we will discuss the marriage of nucleic acids with electrochemical biosensors for the development of rapid clinical tests. These tests integrate both functional nucleic acids (aptamers and DNAzymes) and antibody/DNA complexes for developing barcode-based electrochemical biosensors. The barcode is a DNA strand modified with an electrochemical label that can be detected using an electrochemical chip. Following the presentation of different DNA barcoding methods, we will also present strategies for operating these biosensors in blood, saliva, and urine for direct analysis of clinical samples for the diagnosis of infectious diseases and cancer without the need for target enrichment methods such as growth cultures or nucleic acid amplification. These devices demonstrate the potential for rapid clinical testing at the point-of-need.