Journal article
Ancient Clostridium DNA and variants of tetanus neurotoxins associated with human archaeological remains
Abstract
The analysis of microbial genomes from human archaeological samples offers a historic snapshot of ancient pathogens and provides insights into the origins of modern infectious diseases. Here, we analyze metagenomic datasets from 38 human archaeological samples and identify bacterial genomic sequences related to modern-day Clostridium tetani, which produces the tetanus neurotoxin (TeNT) and causes the disease tetanus. These genomic assemblies …
Authors
Hodgins HP; Chen P; Lobb B; Wei X; Tremblay BJM; Mansfield MJ; Lee VCY; Lee P-G; Coffin J; Duggan AT
Journal
Nature Communications, Vol. 14, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-023-41174-0
ISSN
2041-1723