Structure–activity relationships of tetrahydrocarbazole derivatives as antifungal lead compounds

A Saccharomyces cerevisiae N-myristoyltransferase (NMT) inhibitor bearing a tetrahydrocarbazole scaffold was found to possess broad-spectrum antifungal activity. A series of C6- and N9-modified tetrahydrocarbazole derivatives were designed and synthesized. An in vitro antifungal assay indicated that several tetrahydrocarbazole derivatives showed improved activity with a broad spectrum. Particularly, the inhibitory activity of compound 10c …