Journal article
Peptidoglycan structure of Enterococcus faecium expressing vancomycin resistance of the VanB type
Abstract
Resistance to glycopeptide antibiotics in enterococci is due to the synthesis of UDP-MurNAc-tetrapeptide-D-lactate (where Mur is muramic acid) replacing the normal UDP-MurNAc-pentapeptide precursor. The peptidoglycan structures of an inducible VanB-type glycopeptide-resistant Enterococcus faecium, D366, and its constitutively resistant derivative, MT9, were determined. Using HPLC, 17 muropeptides were identified and were present regardless of …
Authors
BILLOT-KLEIN D; SHLAES D; BRYANT D; David B; van HEIJENOORT J; GUTMANN L
Journal
Biochemical Journal, Vol. 313, No. 3, pp. 711–715
Publisher
Portland Press
Publication Date
February 1, 1996
DOI
10.1042/bj3130711
ISSN
0264-6021