Real-time monitoring of a pharmaceutical process reaction using a membrane interface combined with atmospheric pressure chemical ionisation mass spectrometry

A single-stage membrane-based interface has been developed for real-time mass spectrometric monitoring of the starting materials and products of a highly concentrated pharmaceutical process reaction mixture. The interface was directly connected to the atmospheric pressure chemical ionisation source of a quadrupole mass spectrometer (APCI-MS). Dilution of the concentrated reaction mixture was achieved in a single-step by using the interface with …