Journal article
Crocetin improves the insulin resistance induced by high‐fat diet in rats
Abstract
BACKGROUND AND PURPOSE: The amelioration of insulin resistance by treatment with crocetin is closely related to the hypolipidaemic effect. The present study is designed to clarify the insulin-sensitizing mechanism of crocetin by elucidating the mechanism of regulation of lipid metabolism by crocetin.
EXPERIMENTAL APPROACH: Rats given a high-fat diet were treated with crocetin for 6 weeks before hyperinsulinaemic-euglycaemic clamp. 14C-palmitate …
Authors
Sheng L; Qian Z; Shi Y; Yang L; Xi L; Zhao B; Xu X; Ji H
Journal
British Journal of Pharmacology, Vol. 154, No. 5, pp. 1016–1024
Publisher
Wiley
Publication Date
7 2008
DOI
10.1038/bjp.2008.160
ISSN
0007-1188
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adipose TissueAnimalsBlood GlucoseCarnitine O-PalmitoyltransferaseCarotenoidsDietary FatsDisease Models, AnimalDyslipidemiasFatty Acids, NonesterifiedGlucose Clamp TechniqueHypolipidemic AgentsInsulinInsulin ResistanceLipaseLipoprotein LipaseLipoproteinsLiverMaleMuscle, SkeletalOxidation-ReductionPolymerase Chain ReactionRNA, MessengerRatsRats, WistarTime FactorsTriglyceridesVitamin A