Preprint
The vagus nerve is necessary for the rapid and widespread neuronal activation in the brain following oral administration of psychoactive bacteria
Abstract
Abstract There is accumulating evidence that certain gut microbes modulate brain chemistry and have antidepressant-like behavioural effects. However, it is unclear which brain regions respond to bacteria-derived signals or how signals are transmitted to distinct regions. We investigated the role of the vagus in mediating neuronal activation following oral treatment with Lactobacillus rhamnosus (JB-1). Male Balb/c mice were orally …
Authors
Bharwani A; West C; Champagne-Jorgensen K; Neufeld K-AM; Ruberto J; Kunze WA; Bienenstock J; Forsythe P
DOI
10.1101/860890
Preprint server
bioRxiv