Preprint
Targeting the MR1-MAIT Cell Axis Improves Vaccine Efficacy and Affords Protection against Viral Pathogens
Abstract
Abstract Mucosa-associated invariant T (MAIT) cells are MR1-restricted, innate-like T lymphocytes with tremendous antibacterial and immunomodulatory functions. MAIT cells also sense and respond to viral infections in an MR1-independent fashion. However, whether they can be directly targeted in immunization strategies against viral pathogens is unknown. We addressed this question in multiple wild-type and genetically altered but clinically …
Authors
Rashu R; Ninkov M; Wardell CM; Benoit JM; Wang NI; D’Agostino MR; Zhang A; Feng E; Saeedian N; Bell GI
DOI
10.1101/2023.02.20.529311
Preprint server
bioRxiv