Journal article
An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma
Abstract
PurposeMedulloblastomas (MBs) constitute the most common malignant brain tumor in children and adolescents. MYC-amplified Group 3 MBs are characterized by disease recurrence, specifically in the leptomeninges, whereby patients with these metastatic tumors have a mortality rate nearing 100%. Despite limited research on such tumors, studies on MB metastases at diagnosis suggest targeting kinases to be beneficial.MethodsTo identify kinase …
Authors
Adile AA; Bakhshinyan D; Suk Y; Uehling D; Saini M; Aman A; Magolan J; Subapanditha MK; McKenna D; Chokshi C
Journal
Journal of Neuro-Oncology, Vol. 163, No. 3, pp. 635–645
Publisher
Springer Nature
Publication Date
July 2023
DOI
10.1007/s11060-023-04372-w
ISSN
0167-594X