Preprint
Systematic review of basket trials, umbrella trials, and platform trials: A landscape analysis of master protocols
Abstract
Background: Master protocols, classified as basket trials, umbrella trials, and platform trials, are novel designs that investigate multiple hypotheses through concurrent sub-studies (e.g. multiple treatments or populations, or that allow adding/removing arms during the trial), offering enhanced efficiency and a more ethical approach to trial evaluation. Despite the many advantages of these designs, they are infrequently used. Methods: We …
Authors
Mills EJ; Park JJ; Siden E; Zoratti MJ; Dron L; Harari O; Singer J; Lester RT; Thorlund K
DOI
10.21203/rs.2.9437/v2
Preprint server
Research Square