Preprint
Lipolysis-Derived Linoleic Acid Drives Beige Fat Progenitor Cell Proliferation via CD36
Abstract
De novo beige adipocyte biogenesis involves the proliferation of progenitor cells in white adipose tissue (WAT); however, what regulates this process remains unclear. Here, we report that WAT lipolysis-derived linoleic acid is a potent trigger of beige progenitor cell proliferation following pathophysiological stimuli, including cold acclimation and burn injury. A subset of adipocyte progenitors, as marked by cell surface markers PDGFRα or Sca1 …
Authors
Abe I; Oguri Y; Verkerke ARP; Monteiro LB; Knuth CM; Auger C; Qiu Y; Westcott GP; Cinti S; Shinoda K
Publication date
January 1, 2022
DOI
10.2139/ssrn.4119814
Preprint server
SSRN Electronic Journal