Loss Of  Tet2  In T Cells Drives Translocated Pathobiont Derived Aryl Hydrocarbon Receptor Agonist-Induced Tc1 Cell Autoimmune Hepatitis

Autoimmune hepatitis (AIH) is a progressive, auto-inflammatory liver disorder mediated by interferon-γ (IFNγ)-producing CD8 T cells (Tc1-cells). Here we show that the absence of hematopoietic Tet-methylcytosine-dioxygenase2 (Tet2, Tet2ΔVAV mice), an epigenetic regulator associated with autoimmunity, results in the development of microbiota-dependent AIH-like pathology, accompanied by a hepatic enrichment of aryl-hydrocarbon-receptor (AhR) …