Preprint
Poly ADP-Ribose Signaling is Dysregulated in Huntington Disease
Abstract
Abstract Huntington disease (HD) is a genetic neurodegenerative disease caused by CAG expansion in the Huntingtin (HTT) gene, translating to an expanded polyglutamine tract in the huntingtin (HTT) protein. Age at disease onset correlates to CAG repeat length but varies by decades between individuals with identical repeat lengths. Genome-wide association studies link HD modification to DNA repair and mitochondrial health pathways. Clinical …
Authors
Maiuri T; Bazan CB; Harding RJ; Begeja N; Kam T-I; Byrne LM; Rodrigues FB; Warner MM; Neuman K; Mansoor M
DOI
10.1101/2022.11.23.517669
Preprint server
bioRxiv