A Rapid Fabrication Technique for Self-Assembled Collagen Based Multicellular, Heterogeneous, 3D Tissue Constructs

Although monolayer cell culture models are considered to be the gold standard for in vitro modeling of pathophysiological events, they cannot reconstruct in vivo like gradient of gases and nutrients and lack proper cell-cell and cell-matrix interactions. Spherical cellular aggregates, otherwise known as multicellular spheroids, are widely used as three-dimensional in vitro models to mimic natural in vivo cellular microenvironment for …