Preprint
Medroxyprogesterone acetate mediated alteration in the vaginal microbiota and microenvironment in a Kenyan sex worker cohort
Abstract
Abstract: The hormonal contraceptive Medroxyprogesterone Acetate (MPA) is associated with increased risk of Human Immunodeficiency Virus (HIV), via incompletely understood mechanisms. Increased diversity in the vaginal microbiota modulates genital inflammation and is associated with increased HIV-1 acquisition. However, the effect of MPA on diversity of the vaginal microbiota is relatively unknown. In a cohort of female Kenyan sex workers, …
Authors
Wessels JM; Lajoie J; Cooper MIJH; Omollo K; Felker AM; Vitali D; Dupont HA; Nguyen PV; Mueller K; Vahedi F
DOI
10.1101/483180
Preprint server
bioRxiv