Selection and Application of Catalytically Active Oligonucleotides

The experimental design for selecting catalytically active oligonucleotides is often more dynamic and varied. The process of enriching catalytically active oligonucleotides begins with a large library of diverse sequences. A key decision is to be made at the start of an in vitro selection experiment to determine the length of a random region, which would dictate the diversity of the starting library. As an intermediate in the production of …