Preprint
Randomised Controlled Trial of Rivaroxaban Compared to Standard Anticoagulants for the Treatment of Acute Venous Thromboembolism in Children
Abstract
Background: Treatment of venous thromboembolism (VTE) in children is based on data obtained in adults with little direct documentation of its efficacy and safety in children. Methods: In a parallel-group open-label randomised study, 500 children aged birth to 17 years with documented acute VTE who had started heparinisation were assigned, in a 2:1 ratio, to receive bodyweight-adjusted rivaroxaban (tablets or suspension) in a 20-mg equivalent …
Authors
Male C; Lensing AWA; Palumbo JS; Kumar R; Nurmeev I; Hege K; Bonnet D; Connor P; Hooimeijer HL; Torres M
Publication date
January 1, 2019
DOI
10.2139/ssrn.3403353
Preprint server
SSRN Electronic Journal