Preprint
Virus-Intrinsic Differences and Heterogeneous IRF3 Activation Influence IFN-Independent Antiviral Protection
Abstract
Type 1 interferon (IFN) plays a critical role in early antiviral defense and priming of adaptive immunity by upgregulating interferon-stimulated genes (ISGs). Certain stimuli trigger strong activation of IFN regulatory factor 3 (IRF3) and direct upregulation of ISGs in addition to IFN. We found that UV-inactivated human cytomegalovirus (HCMV) particles triggered an IFN-independent ISG signature while UV-inactivated Sendai virus (SeV) particles …
Authors
Hare DN; Baid K; Dvorkin-Gheva A; Mossman K
Publication date
January 1, 2020
DOI
10.2139/ssrn.3565041
Preprint server
SSRN Electronic Journal