Covalent Stabilization of Antibody Recruitment Enhances Immune Recognition of Cancer Targets

Antibody recruiting molecules (ARMs) represent an important class of chemical tools with therapeutic potential. ARMs function by simultaneously binding to a hapten specific serum antibody (Ab) and a cancer cell surface protein, thereby forming ARM:Ab complexes on the cancer cell surface. These complexes activate immune cell recognition and elimination of the cancer cell. Problematically, ARM function in human patients may be limited by …