Preprint
A Covalent Opsonization Approach to Enhance Synthetic Immunity Against Viral Escape Variants
Abstract
CoVID-19 has highlighted the need for rapidly deployable therapeutics in the event of future pandemics. Monoclonal Antibodies (mAbs) represent an effective anti-viral immunotherapy, operating through multiple potential mechanisms of action, namely viral entry blockade and immune engagement. Mutations in viral surface proteins however can lead to “escape mutants” no longer recognized by therapeutic antibodies which are intrinsically highly …
Authors
Kapcan E; Rullo AF
Publication date
January 1, 2022
DOI
10.2139/ssrn.4273246
Preprint server
SSRN Electronic Journal