Gene regulatory changes underlie developmental plasticity in respiration and aerobic performance in highland deer mice

Abstract Phenotypic plasticity can play an important role in the ability of animals to tolerate environmental stress, but the nature and magnitude of plastic responses are often specific to the developmental timing of exposure. Here, we examine changes in gene expression in the diaphragm of highland deer mice ( Peromyscus maniculatus ) in response to hypoxia exposure at different stages of development. In highland deer mice, developmental …