Journal article
The Effect of Ketoconazole on Post-Burn Inflammation, Hypermetabolism and Clinical Outcomes
Abstract
BACKGROUND: Hypercortisolemia has been suggested as a primary hormonal mediator of whole-body catabolism following severe burn injury. Ketoconazole, an anti-fungal agent, inhibits cortisol synthesis. We, therefore, studied the effect of ketoconazole on post-burn cortisol levels and the hyper-catabolic response in a prospective randomized trial (block randomization 2:1).
METHODOLOGY/PRINCIPAL FINDINGS: Fifty-five severely burned pediatric …
Authors
Jeschke MG; Williams FN; Finnerty CC; Rodriguez NA; Kulp GA; Ferrando A; Norbury WB; Suman OE; Kraft R; Branski LK
Journal
PLOS ONE, Vol. 7, No. 5,
Publisher
Public Library of Science (PLoS)
Publication Date
2012
DOI
10.1371/journal.pone.0035465
ISSN
1932-6203