233 Metformin Increases Mitochondrial Coupling and Enhances Antioxidant Activity in the Kidneys of Aged Mice Following Thermal Trauma

Following thermal trauma, a systemic increase in pro-inflammatory mediators and hyperglycemia may culminate in multiple organ dysfunction, sepsis, and ultimately, death. This is particularly true in the elderly population, who are prone to organ failure and adverse outcomes following burn injury. We have recently demonstrated that in patients, metformin administration is equal to insulin in its ability to limit stress-induced hyperglycemia, yet …