Journal article
Salt‐inducible kinase 1 links p300 phosphorylation to CREB regulated gluconeogenesis post burn
Abstract
Severe burn injury results in sustained catecholamine release and increased cyclic AMP (cAMP) levels. cAMP‐induced inhibition of salt‐inducible kinase 1 (SIK1) has been shown to promote recruitment of the transcriptional co‐activator p300 to cAMP response element binding protein (CREB), resulting in gluconeogenesis. Gluconeogenesis is increased and maintained post‐burn injury yet the molecular mechanism is unknown. We hypothesize that …
Authors
Brooks NC; Smith AH; Hiyama Y; Finnerty CC; Herndon DN; Boehning D; Jeschke MG
Journal
The FASEB Journal, Vol. 26, No. S1, pp. 758.7–758.7
Publisher
Wiley
Publication Date
April 2012
DOI
10.1096/fasebj.26.1_supplement.758.7
ISSN
0892-6638