Journal article
Systemic Inflammatory and Th17 Immune Activation among Patients Treated for Lumbar Radiculopathy Exceeds that of Patients Treated for Persistent Postoperative Neuropathic Pain
Abstract
BACKGROUND: The pathophysiology of lumbar radiculopathy includes both mechanical compression and biochemical irritation of apposed neural elements. Inflammatory and immune cytokines have been implicated, induced by systemic exposure of immune-privileged intervertebral disc tissue. Surgical intervention provides improved symptoms and quality of life, but persistent postoperative neuropathic pain (PPNP) afflicts a significant fraction of …
Authors
Shamji MF; Guha D; Paul D; Shcharinsky A
Journal
Neurosurgery, Vol. 81, No. 3, pp. 537–544
Publisher
Wolters Kluwer
Publication Date
September 2017
DOI
10.1093/neuros/nyx052
ISSN
0148-396X