Journal article
Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2
Abstract
BackgroundThe distribution of ovarian tumour characteristics differs between germline BRCA1 and BRCA2 pathogenic variant carriers and non-carriers. In this study, we assessed the utility of ovarian tumour characteristics as predictors of BRCA1 and BRCA2 variant pathogenicity, for application using the American College of Medical Genetics and the Association for Molecular Pathology (ACMG/AMP) variant classification system.MethodsData for 10,373 …
Authors
O’Mahony DG; Ramus SJ; Southey MC; Meagher NS; Hadjisavvas A; John EM; Hamann U; Imyanitov EN; Andrulis IL; Sharma P
Journal
British Journal of Cancer, Vol. 128, No. 12, pp. 2283–2294
Publisher
Springer Nature
Publication Date
June 29, 2023
DOI
10.1038/s41416-023-02263-5
ISSN
0007-0920