Journal article
Drug-drug interactions between direct oral anticoagulants and anticonvulsants and clinical outcomes: A systematic review
Abstract
Background: Direct oral anticoagulants (DOACs) are widely used in patients with atrial fibrillation and venous thromboembolism. However, DOACs have important potential drug-drug interactions (DDIs) with several classes of drugs. In particular, antiepileptic (AE) drugs may induce cytochrome P450 3A4 or P-glycoprotein. Co-administration of DOACs and AE drugs may result in lower DOAC drug levels and reduced DOAC efficacy. However, the clinical …
Authors
Candeloro M; Carlin S; Shapiro MJ; Douketis JD
Journal
Research and Practice in Thrombosis and Haemostasis, Vol. 7, No. 3,
Publisher
Elsevier
Publication Date
March 2023
DOI
10.1016/j.rpth.2023.100137
ISSN
2475-0379