The gut—brain axis in IBD: an investigator’s perspective

The gut—brain axis is a neurohumoral bidirectional communication network that integrates behavior and intestinal function. Brain-to-gut communication is evident in many demonstrations of central nervous system (CNS) control of intestinal physiology, including motility and acid secretion. This may be relevant to the pathogenesis of functional bowel disease and stress-induced peptic ulceration. Gut-to-brain communication is reflected in studies …