A3 A SERPIN-PRODUCING BIFIDOBACTERIA IMPROVES GLUTEN PATHOLOGY IN MICE

Celiac disease (CeD) is an autoimmune disorder triggered by gluten. The only treatment for CeD is a gluten-free diet, hence, there is need for adjunctive therapies. The restoration of protease/anti-protease balance in chronic intestinal disorders has become a therapeutic target. We have previously demonstrated the efficacy of the human anti-protease, elafin, expressed transgenically by Lactococcus lactis, in attenuating gluten-induced pathology …