A279 COLONIZATION WITH PROTEOLYTIC BACTERIA INDUCES LOW-GRADE INFLAMMATION AND BARRIER DYSFUNCTION IN MICE

In the gastrointestinal tract, proteases regulate motility, immunity, mucus cleavage, wound healing and tissue remodeling. A proteolytic imbalance has been described in inflammatory bowel disease, irritable bowel syndrome and celiac disease, but it is unclear if this imbalance is an initiator or consequence of disease. Most studies focus on host-derived proteases, while the role of bacterial proteases are poorly understood. We investigated the …