Journal article
A50 MICROBIOTA-MAST CELL INTERACTIONS IN A HUMANIZED MOUSE MODEL OF IBS
Abstract
Accumulating evidence suggests that mast cells play an important role in the pathogenesis of Irritable Bowel Syndrome (IBS). Colonic mast cells are increased in patients with IBS, and their products, including histamine and tryptase are putative mediators of visceral hypersensitivity in IBS. To investigate the effect of gut microbiota on mast cells in a humanized mouse model of IBS. Germ-free NIH Swiss mice were colonized with fecal microbiota …
Authors
Shimbori C; De Palma G; Lu J; Verdu E; Collins SM; Reed DE; Vanner S; Bercik P
Journal
Journal of the Canadian Association of Gastroenterology, Vol. 2, No. Supplement_2, pp. 99–100
Publisher
Oxford University Press (OUP)
Publication Date
March 15, 2019
DOI
10.1093/jcag/gwz006.049
ISSN
2515-2084